Each Synchromesh unit plays back one or more tracks, and in each of those tracks has two sides - next and current. When one clip is playing, another clip can be pre-cued cleanly and made ready to play. On cue, all Synchromesh channels can cleanly transition to the pre-loaded next clip.

The default video transition is a dissolve (with a hand-tuned fade curve), and for audio, a cross-fade. Other transitions can be loaded in as MeshScripts, including complex 3D flips or alpha channel transitions.

Transitions are carried out at full frame rate, in exact sync between units.